Title : Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by 1 rifampicin - resistant , rpoB - mutant Mycobacterium tuberculosis 2 3 Running title : PDIM locus upregulation by rpoB - mutant M . tuberculosis 4 5
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چکیده
Title: Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by 1 rifampicin-resistant, rpoB-mutant Mycobacterium tuberculosis 2 3 Running title: PDIM locus upregulation by rpoB-mutant M. tuberculosis 4 5 Gregory P. Bisson, Carolina Mehaffy, Corey Broeckling, Jessica Prenni, Dalin 6 Rifat, Desmond S. Lun, Marcos Burgos, Drew Weissman, Petros C. Karakousis, 7 Karen Dobos 8 9 Division of Infectious Diseases, Department of Medicine, The Perelman School of 10 Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of 11 America 12 Center for Clinical Epidemiology and Biostatistics, The Perelman School of Medicine at 13 the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America 14 Department of Microbiology, Immunology, and Pathology, and Proteomics and 15 Metabolomics Facility, Colorado State University, Fort Collins, CO, United States of 16 America 17 Center for Tuberculosis Research, Johns Hopkins University School of Medicine, 18 Baltimore, Maryland, United States of America 19 Center for Computational and Integrative Biology and Department of Computer 20 Science, Rutgers University, Camden, New Jersey, United States of America 21 Phenomics and Bioinformatics Research Centre and School of Mathematics and 22 Statistics, University of South Australia, Mawson Lakes, South Australia, Australia 23 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.01013-12 JB Accepts, published online ahead of print on 21 September 2012
منابع مشابه
Mutations in the RpoB Gene of Multidrug-Resistant Mycobacterium Tuberculosis Isolates from Semarang, Indonesia
ABSTRACTTuberculosis is an infectious disease which occurs widely in the world and becomes one of the top 10 causes of death worldwide. Mutations of the RpoB gene cause the resistance of Mycobacterium tuberculosis to rifampicin that contributes to the occurrence of MDR-TB. This study aimed to determine the pattern of rpoB gene polymorphisms in the MDR M. tuberculosis in Semarang, Indonesia. Mos...
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AIMS Phthiocerol dimycocerosate (PDIM) waxes and other lipids are necessary for successful Mycobacterium tuberculosis infection, although the exact role of PDIM in host-pathogen interactions remains unclear. In this study, we investigated the contribution of tesA, drrB, pks6 and pks11 genes in complex lipid biosynthesis in M. tuberculosis. METHODS AND RESULTS Four mutants were selected from M...
متن کاملCharacterization of Mutations in the Rpob and Katg Gene of Mycobacterium Tuberculosis Isolates From Pasteur Institute of Tehran
Objective: The Rifampicin resistance and susceptibility of Mycobacterium tuberculosis are caused by mutations in the 81-base pair region of the rpoB gene encoding the b-subunit of RNA polymerase. Methods: Isoniazid resistance of M. tuberculosis is related to mutations in inha , oxyR and ahpC genes which 30 to 90 percent of Isoniazid resistance is occurred in 3015 codons of kat...
متن کاملCharacterization of Mutations in the Rpob and Katg Gene of Mycobacterium Tuberculosis Isolates From Pasteur Institute of Tehran
Objective: The Rifampicin resistance and susceptibility of Mycobacterium tuberculosis are caused by mutations in the 81-base pair region of the rpoB gene encoding the b-subunit of RNA polymerase. Methods: Isoniazid resistance of M. tuberculosis is related to mutations in inha , oxyR and ahpC genes which 30 to 90 percent of Isoniazid resistance is occurred in 3015 codons of kat...
متن کاملInteraction between Polyketide Synthase and Transporter Suggests Coupled Synthesis and Export of Virulence Lipid in M. tuberculosis
Virulent mycobacteria utilize surface-exposed polyketides to interact with host cells, but the mechanism by which these hydrophobic molecules are transported across the cell envelope to the surface of the bacteria is poorly understood. Phthiocerol dimycocerosate (PDIM), a surface-exposed polyketide lipid necessary for Mycobacterium tuberculosis virulence, is the product of several polyketide sy...
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